Unlocking Amylase Test Insights

By Dr. Priya Sammani ( MBBS, DFM )

It often starts with that unsettling feeling in your stomach, doesn’t it? A pain that just won’t quit, or maybe a general sense that something’s off. Sometimes, when you come to see me with symptoms like these, especially if they’re pointing towards your pancreas, one of the first things we might talk about is an amylase test. It’s a simple test, really, but it can give us some important clues about what’s happening inside your body.

So, What Exactly is This Amylase Test?

Let’s break it down. An amylase test measures the amount of a specific enzyme called amylase in your blood or, sometimes, in your urine. You might hear us call it an “amy” test, or more formally, a serum amylase (for blood) or urine amylase.

Now, what’s amylase? Think of it as one of your body’s little helpers. It’s a protein, an enzyme to be precise, that your pancreas and the salivary glands in your mouth produce. Its main job? To help your body break down carbohydrates from the food you eat. It’s perfectly normal to have a small amount of amylase circulating in your blood and present in your urine. But if those levels are too high, or sometimes too low, it can be a sign that we need to investigate a bit further.

Why Would We Order an Amylase Test?

I might suggest an amylase test if I’m trying to figure out or keep an eye on a few different things. Often, it’s when we suspect an issue with the pancreas. This could be:

  • Pancreatitis: This is an inflammation of the pancreas, and it’s probably the most common reason we check amylase.
  • Gallstones: Sometimes these can block the ducts around the pancreas.
  • Pancreatic cancer: Though less common, it’s something we consider.

But it’s not just about the pancreas. Other situations where this test can be helpful include:

  • Concerns about alcohol use disorder, as heavy alcohol use can affect the pancreas.
  • Managing cystic fibrosis, a condition that can impact digestive enzyme production.
  • If there are signs of certain eating disorders.
  • Sometimes, to check for specific infections.

Who Does the Test?

If it’s a blood test, one of our nurses, a lab technician, or even myself might draw the blood. If it’s a urine test, you’ll provide the sample. Then, off it goes to the lab where the clever folks there do the actual measuring.

Getting Ready for Your Amylase Test

I’ll always give you specific instructions, but here are some general things to keep in mind.

  • Fasting: You might need to fast – that means no food or drink except water – for about 8 to 12 hours before the test.
  • Alcohol: It’s usually best to avoid alcohol for 24 hours beforehand.
  • Medications: This is really important. Please tell me about all medications you’re taking. That includes prescriptions, over-the-counter drugs, and even supplements. Some common ones that can affect amylase levels include:
  • Aspirin
  • Corticosteroids
  • Diuretics (often called water pills)
  • Indomethacin (an anti-inflammatory)
  • Opioids (strong pain relievers)
  • Oral contraceptives (birth control pills)

Don’t worry, just let me know, and we can figure out if any adjustments are needed.

What Happens During the Test?

It’s pretty straightforward, honestly.

For a Blood Amylase Test:

This part is quick, just a few minutes.

  1. We’ll wrap a snug band around your upper arm. This helps your veins pop up a bit.
  2. Then, we’ll clean a small patch of skin, usually on the inside of your elbow.
  3. A small needle will be inserted. You might feel a little pinch or a sting – it’s over in a second.
  4. A tube is attached to the needle, and we’ll collect a small sample of your blood.
  5. Once we have enough, the band and needle come out.
  6. We’ll put a bit of pressure on the spot to stop any bleeding, and then a small bandage goes on. Easy peasy.

For a Urine Amylase Test:

For a urine sample, I might ask for what’s called a “clean catch” sample right here in the clinic. Or, sometimes, we need to collect all your urine over a 24-hour period at home. I’ll give you all the details and any special containers you might need.

Generally, for a clean catch:

  1. Wash your hands well.
  2. You’ll use a special cleansing pad to clean your genital area. For men, that’s the tip of the penis. For women, it’s wiping the folds around the vagina from front to back.
  3. Start to urinate a little into the toilet first, then stop the stream.
  4. Then, position the collection cup under the stream and collect pee until it reaches the marked line on the cup.
  5. Finish urinating into the toilet.
  6. Wash your hands again, and give the cup back to us.

After the Amylase Test

If you had a blood test, just keep the bandage on for a few hours. You might want to take it easy and avoid any strenuous exercise for a little while too.

For a urine test, there’s nothing special you need to do afterward.

Are There Any Risks?

Blood tests are very safe. You might get a tiny bruise where the needle went in – that’s pretty common. Rarely, the vein might get a bit swollen or tender. If that happens, a warm compress can help.

With urine tests, there really aren’t any known risks.

Understanding Your Amylase Test Results

Usually, we get the results back from the lab in a day or two. I know waiting can be the hardest part.

What’s a “Normal” Amylase Level?

It’s good to know that “normal” can vary a little from lab to lab. They all have slightly different ways of measuring things.

  • For a blood sample, a typical range is something like 30 to 110 units per liter (U/L).
  • For a urine sample, the range is often around 2.6 to 21.2 international units per hour (IU/h).

But please, don’t get too hung up on these numbers yourself. That’s what I’m here for.

What if My Amylase is High or Low?

If your amylase level isn’t in the typical range, it doesn’t automatically mean something terrible. It’s just a piece of the puzzle.

  • High amylase levels often point towards an issue with your pancreas, like pancreatitis. But, as we talked about, other things can cause it too.
  • Low amylase levels are less common but might suggest a problem with your pancreas not making enough enzymes, or potentially issues with your liver or kidneys. Sometimes it’s seen in cystic fibrosis.

I’ll always sit down with you to discuss your results. We’ll look at them alongside how you’re feeling, your medical history, and any other tests we might have done. It’s all about putting the whole picture together.

Take-Home Message: Key Things About Your Amylase Test

Here’s a quick rundown of what we’ve covered:

  • An amylase test measures a digestive enzyme, mainly from your pancreas and salivary glands.
  • It’s often used to check for pancreas problems like pancreatitis.
  • You might need to fast or avoid certain medications before the test – I’ll let you know.
  • The test involves a simple blood draw or providing a urine sample.
  • Results help us understand what might be going on, but they’re just one part of the diagnostic process. We’ll figure out what your specific amylase test results mean for you, together.

Whatever the results, please know we’ll talk through all the options and next steps. You’re not alone in this.

Dr. Priya Sammani
Medically Reviewed by
MBBS, Postgraduate Diploma in Family Medicine
Dr. Priya Sammani is the founder of Priya.Health and Nirogi Lanka. She is dedicated to preventive medicine, chronic disease management, and making reliable health information accessible for everyone.
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